Project 1

Determine if Ascorbate can reduce metastatic disease in pancreatic cancer

Project 2

Determine if Ascorbate can exploit labile ion pools for improving non-small cell lung cancer (NSCLC) outcome with radio -chemo-therapy

Project 3

MR imaging of ascorbate induced radio-chemo-sensitization and redox active iron in the glioblastoma multiforme (GBM)

Clinical Trials

IND sponsor at the University of Iowa for the following clinical trials:

NCT01049880: A research trial of high dose vitamin C and chemotherapy for metastatic pancreatic cancer (J. Cullen MD, Clinical Investigator)

NCT01752491:  A phase I trial of high-dose ascorbate in glioblastoma multiforme  (J. M. Buatti, MD, Clinical Investigator)

NCT01852890: Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase 1  (J. Cullen MD, Clinical Investigator)

NCT02420314: A Phase 2 Trial of High-Dose Ascorbate in Stage IV Non-Small Cell Lung Cancer (M. Furqan, MD, Clinical Investigator)

NCT02344355: A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme  (B. Allen, MD, PhD, Clinical Investigator)

NCT02905578: A Phase 2 Trial of Pharmacological Ascorbate, Gemcitabine, and nab-Paclitaxel for Metastatic Pancreatic Cancer (PACMAN 2.1) (J. Cullen MD, Clinical Investigator)

NCT02905591: A Phase II Trial of Pharmacological Ascorbate with Concurrent Chemotherapy and Radiation Therapy for Non-Small Cell Lung Cancer  (XACT-LUNG) (B. Allen MD PhD, Clinical Investigator)