Publications

1. Alexander MS, O’Leary BR, Moose D, Du J, Henry MD, Cullen JJ. A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells. J Biol Methods. 2018 Sep 5;5(3):e97. doi: 10.14440/jbm.2018.250. PMID: 31453247; PMCID: PMC6706145.
2. Schoenfeld JD, Alexander MS, Waldron TJ, Sibenaller ZA, Spitz DR, Buettner GR, Allen BG, Cullen JJ. Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue. Semin Radiat Oncol. 2019 Jan;29(1):25-32. doi: 10.1016/j.semradonc.2018.10.006. PMID: 30573181; PMCID: PMC6310038.
3. Alexander MS, Cullen JJ. Treating pancreatic cancer: more antioxidants more problems? Expert Rev Gastroenterol Hepatol. 2018 Sep;12(9):849-851. doi: 10.1080/17474124.2018.1494572. Epub 2018 Jul 5. PMID: 29956580; PMCID: PMC6317716.
4. O’Leary BR, Houwen FK, Johnson CL, Allen BG, Mezhir JJ, Berg DJ, Cullen JJ, Spitz DR. Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. Radiat Res. 2018 May;189(5):456-465. doi: 10.1667/RR14978.1. Epub 2018 Mar 16. PMID: 29547353; PMCID: PMC6117840.
5. Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA. Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol. 2018 Apr;14:82-87. doi: 10.1016/j.redox.2017.08.017. Epub 2017 Aug 26. Erratum in: Redox Biol. 2018 Jun 8;: PMID: 28886484; PMCID: PMC5591450.
6. Alexander MS, Wilkes JG, Schroeder SS, Buettner GR, Gibson-Corley K, O’Leary BR, Spitz DR, Buatti JM, Berg DJ, Bodeker KL, Vollstedt S, Brown HA, Allen BL, Cullen JJ. Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Cancer Research, 78:6838-6851, 2018 DOI:10.1158/0008-5472.CAN-18-1680. NIHMS 1511241
7. Alexander MS, O’Leary BR, Wilkes JG, Gibson AR, Wagner BA, Du J, Sarsour E, Hwang RF, Buettner GR, Cullen JJ. Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer. Radiation Research 191:43-51, 2019. NIHMS 1008361.
8. Cullen JJ. The dual effect of pharmacological ascorbate on radiation: the best of both worlds. Oncotarget, 2018 Nov 30;9(94):36648-36649. doi: 10.18632/oncotarget.26396..
9. Cullen JJ, Alexander MS. Pharmacological Ascorbate as a Radiosensitizer. In Part II, Mechanism of Action for Vitamin C in Cancer. Chapter 5, IN: Cancer and Vitamin C. Edited by Qi Chen and Jeanne Drisko. CRC press. 2019.
10. Petronek MS, Wagner BA, Hollenbeck NJ, Caster JM, Spitz DR, Cullen JJ, Buettner GR, Allen BG. Assessment of the stability of supra-physiological ascorbate in human blood: Appropriate handling of samples from clinical trials for measurements of pharmacological ascorbate. Radiation Research, 2019 Jun;191(6):491-496. doi: 10.1667/RR15328.1. 2019.
11. Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer SL, Cullen JJ, Buettner GR. Pharmacological Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage. Molecular Cancer Research, 17:2102-2114, 2019 10.1158/1541-7786.MCR-19-0381.
12. Allen B, Bodeker K, Smith M, Monga V, Sandhu S, Hohl R, Carlisle T, Brown H, Hollenbeck N, Vollstedt S, Greenlee J, Howard M, Seyedin S, Caster J, Jones K, Cullen J, Berg D, Wagner B, Buettner G, TenNapel M, Smith B, Spitz D, Buatti J. First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clinical Cancer Research 25:6591-6597, 2019. DOI: 10.1158/1078-0432.
13. Klener P, Alexander MS, Cullen JJ, Stejskal V, Slíva J, Kotlářová L, Kostiuk P, Procházka Z, Kučerová M. The benefits of ascorbate to protect healthy cells in the prevention and treatment of oncological diseases. Journal of Applied Biomedicine. P. 1-7, 2020DOI: 10.32725/jab.2020.003
14. Gibson AR, O’Leary BR, Du J, Sarsour EH, Kalen AL, Wagner BA, Stolwijk JM, Falls-Hubert KC, Alexander MS, Carroll RS, Spitz DR, Buettner GR, Goswami PC, Cullen JJ. Dual oxidase-induced sustained generation of hydrogen peroxide contributes to pharmacological ascorbate-induced toxicity. Cancer Research, 80:1401-1413, 2020. doi: 10.1158/0008-5472.CAN-19-3094.
15. Sarsour EH, Son JM, Kalen AL, Xio W, Du J, Alexander MS, O’Leary BR, Cullen JJ, Goswami PC. Arachidonate 12-Lipoxygenase and 12-Hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. Journal of Biological Chemistry. 295:6946-6957, 2020. PMID: 32265301 PMCID: PMC7242692
16. Carroll RS, Buettner GR, Cullen JJ. Pharmacological Ascorbate and Use in Pancreatic Cancer. IN: Cancer: Oxidative Stress and Dietary Antioxidants. Edited by Victor Preedy. In press.
17. O’Leary BR, Alexander MS, Du J, Moose DL, Henry MD, Cullen JJ. Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism. Scientific Reports, (2020) 10:17649. doi.org/10.1038/s41598-020-74806-2. PMID: 33077776 PMCID: PMC7572461
18. Cushing CM, Petronek MS, Bodeker KL, Vollstedt S, Brown HA, Opat E, Hollenbeck NJ, Shanks T, Berg DJ, Smith BJ, Smith MC, Monga V, Furqan M, Howard MA, Greenlee JD, Mapuskar KA, St-Aubin J, Flynn RT, Cullen JJ, Buettner GR, Spitz DR, Buatti JM, Allen BG, Magnotta VA. Magnetic Resonance Imaging (MRI) of Pharmacological Ascorbate-Induced Iron Redox State as a Biomarker in Subjects Undergoing Radio-Chemotherapy. Redox Biology, in press https://doi.org/10.1016/j.redox.2020.101804.